The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
| Pack Size | 100ul, 1ml, 20ul | 
|---|---|
| Applications | ELISA, WB | 
| Host Species | Rabbit | 
| Ig Isotype | IgG | 
| Antibody Type | Monoclonal Antibody | 
| Organism Species | Human | 
| Product Synonyms | Cofilin | 
| Observed Mol Wt | 19kDa | 
| Alternative Names | CFL; cofilin; HEL-S-15; Cofilin | 
| Immunogen (Antigen) | synthetic peptide | 
| Format | Liquid | 
| Buffer Formulation | 0.05% BSA, 50% glycerol, PBS with 0.02% sodium azide, pH7.3 | 
| Reactivity | Human, Mouse, Rat | 
| Uniprot ID | 1072 | 
| Gene ID | P23528 | 
| Potency (Clone Number) | ARC2615 | 
| Purification | Antigen-specific affinity chromatography followed by Protein A affinity chromatography | 
| Usage | For Research Use Only. Not for diagnostics or human use. | 
| Shelf Life | 12 months at time of shipping | 
| Shipping | Shipped in Dry Ice at -20 Degree Celsius | 
| Storage | Store at -20 Degree Celsius. It is recommended to aliquot and store to avoid repeated freeze-thaw as it affects the stability of the antibody. | 
| Research Areas | Cancer, Cell Adhesion, Cell Biology, Immunology, Inflammation, Neuroscience | 
| KD/KO Validated | KD Validated | 
| Disclaimer | The data indicated herein are as indicated and validated in our laboratory. These reagents are for research use only and not for in-vitro diagnostics or human use. | 
 
				    
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