The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.
| Pack Size | 100ul, 1ml, 20ul | 
|---|---|
| Applications | ELISA, IF/ICC, WB | 
| Host Species | Rabbit | 
| Ig Isotype | IgG | 
| Antibody Type | Polyclonal Antibody | 
| Organism Species | Human | 
| Concentration | – | 
| Product Synonyms | ABCB11 | 
| Observed Mol Wt | 146kDa | 
| Alternative Names | ABC16, ABCB11, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP | 
| Immunogen (Antigen) | synthetic peptide | 
| Format | Liquid | 
| Buffer Formulation | 50% glycerol, PBS with 0.09% Sodium azide, pH7.3 | 
| Reactivity | Human, Mouse, Rat | 
| Uniprot ID | 8647 | 
| Gene ID | O95342 | 
| Purification | Antigen-specific affinity chromatography followed by Protein A affinity chromatography | 
| Usage | For Research Use Only. Not for diagnostics or human use. | 
| Shelf Life | 12 months at time of shipping | 
| Shipping | Shipped in Dry Ice at -20 Degree Celsius | 
| Storage | Store at -20 Degree Celsius. It is recommended to aliquot and store to avoid repeated freeze-thaw as it affects the stability of the antibody. | 
| Research Areas | Cancer, Cell Biology, Immunology | 
| KD/KO Validated | KD Validated | 
| Disclaimer | The data indicated herein are as indicated and validated in our laboratory. These reagents are for research use only and not for in-vitro diagnostics or human use. | 
 
				    
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