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Cell Biology

Alpha-2-Macroglobulin (A2M) Rabbit Polyclonal Antibody

Name: Alpha-2-Macroglobulin (A2M) Rabbit Polyclonal Antibody
SKU: KDXB201263
Availability: InStock

$80.00 – $350.00

SKU:KDXB201263 Categories:Polyclonal Antibodies

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer’s disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.

Pack Size	100ul, 1ml, 20ul
Applications	ELISA, WB
Host Species	Rabbit
Ig Isotype	IgG
Antibody Type	Polyclonal Antibody
Organism Species	Human
Product Synonyms	Alpha-2-Macroglobulin (A2M)
Observed Mol Wt	163kDa
Alternative Names	A2MD; CPAMD5; FWP007; S863-7; Alpha-2-Macroglobulin (A2M)
Immunogen (Antigen)	Recombinant protein
Format	Liquid
Buffer Formulation	50% glycerol, PBS with 0.09% Sodium azide, pH7.3
Reactivity	Human, Mouse, Rat
Uniprot ID	2
Gene ID	P01023
Purification	Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Usage	For Research Use Only. Not for diagnostics or human use.
Shelf Life	12 months at time of shipping
Shipping	Shipped in Dry Ice at -20 Degree Celsius
Storage	Store at -20 Degree Celsius. It is recommended to aliquot and store to avoid repeated freeze-thaw as it affects the stability of the antibody.
Research Areas	Cell Biology; Developmental Biology; Immunology
KD/KO Validated	KD Validated
Disclaimer	The data indicated herein are as indicated and validated in our laboratory. These reagents are for research use only and not for in-vitro diagnostics or human use.