In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
| Pack Size | 100ul, 1ml, 20ul | 
|---|---|
| Applications | ELISA, IF/ICC | 
| Host Species | Rabbit | 
| Ig Isotype | IgG | 
| Antibody Type | Polyclonal Antibody | 
| Organism Species | Human | 
| Product Synonyms | ASIP | 
| Observed Mol Wt | 15kDa | 
| Alternative Names | ASP; AGSW; AGTI; AGTIL; SHEP9; ASIP | 
| Immunogen (Antigen) | Recombinant protein | 
| Format | Liquid | 
| Buffer Formulation | 50% glycerol, PBS with 0.02% sodium azide, pH7.3 | 
| Reactivity | Human, Mouse | 
| Uniprot ID | 434 | 
| Gene ID | P42127 | 
| Purification | Antigen-specific affinity chromatography followed by Protein A affinity chromatography | 
| Usage | For Research Use Only. Not for diagnostics or human use. | 
| Shelf Life | 12 months at time of shipping | 
| Shipping | Shipped in Dry Ice at -20 Degree Celsius | 
| Storage | Store at -20 Degree Celsius. It is recommended to aliquot and store to avoid repeated freeze-thaw as it affects the stability of the antibody. | 
| Research Areas | Cancer; Cell Biology; Immunology; Neuroscience; Growth Factors; | 
| KD/KO Validated | KD Validated | 
| Disclaimer | The data indicated herein are as indicated and validated in our laboratory. These reagents are for research use only and not for in-vitro diagnostics or human use. | 
 
				    
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