Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
| Pack Size | 100ul, 1ml, 20ul | 
|---|---|
| Applications | ELISA, IF/ICC, IHC-P, WB | 
| Host Species | Rabbit | 
| Ig Isotype | IgG | 
| Antibody Type | Polyclonal Antibody | 
| Organism Species | Human | 
| Product Synonyms | Ataxin-3 (ATXN3) | 
| Observed Mol Wt | 41kDa | 
| Alternative Names | AT3; JOS; MJD; ATX3; MJD1; SCA3; Ataxin-3 (ATXN3) | 
| Immunogen (Antigen) | Recombinant protein | 
| Format | Liquid | 
| Buffer Formulation | 50% glycerol, PBS with 0.05% proclin300, pH7.3 | 
| Reactivity | Human, Mouse, Rat | 
| Uniprot ID | 4287 | 
| Gene ID | P54252 | 
| Purification | Antigen-specific affinity chromatography followed by Protein A affinity chromatography | 
| Usage | For Research Use Only. Not for diagnostics or human use. | 
| Shelf Life | 12 months at time of shipping | 
| Shipping | Shipped in Dry Ice at -20 Degree Celsius | 
| Storage | Store at -20 Degree Celsius. It is recommended to aliquot and store to avoid repeated freeze-thaw as it affects the stability of the antibody. | 
| Research Areas | Neuroscience; | 
| KD/KO Validated | KD Validated | 
| Disclaimer | The data indicated herein are as indicated and validated in our laboratory. These reagents are for research use only and not for in-vitro diagnostics or human use. | 
 
				    
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