This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress.
Pack Size | 100ul, 1ml, 20ul |
---|---|
Applications | ELISA, IF/ICC, IHC-P, IP, WB |
Host Species | Rabbit |
Ig Isotype | IgG |
Antibody Type | Polyclonal Antibody |
Organism Species | Human |
Concentration | – |
Product Synonyms | GDF15 |
Observed Mol Wt | 34kDa |
Alternative Names | PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15; GDF15 |
Immunogen (Antigen) | Recombinant protein |
Format | Liquid |
Buffer Formulation | 50% glycerol, PBS with 0.01% thimerosal, pH7.3 |
Reactivity | Human, Mouse, Rat |
Uniprot ID | 9518 |
Gene ID | Q99988 |
Purification | Antigen-specific affinity chromatography followed by Protein A affinity chromatography |
Usage | For Research Use Only. Not for diagnostics or human use. |
Shelf Life | 12 months at time of shipping |
Shipping | Shipped in Dry Ice at -20 Degree Celsius |
Storage | Store at -20 Degree Celsius. It is recommended to aliquot and store to avoid repeated freeze-thaw as it affects the stability of the antibody. |
Research Areas | Bone Metabolism, Cancer, Cell Biology, Growth factors, Immunology, Inflammation |
KD/KO Validated | KD Validated |
Disclaimer | The data indicated herein are as indicated and validated in our laboratory. These reagents are for research use only and not for in-vitro diagnostics or human use. |
Related Products
-
Sale
Select options This product has multiple variants. The options may be chosen on the product page Quick View View wishlist -
Sale
Select options This product has multiple variants. The options may be chosen on the product page Quick View Add to wishlist -
Sale
Select options This product has multiple variants. The options may be chosen on the product page Quick View Add to wishlist -
Sale
Select options This product has multiple variants. The options may be chosen on the product page Quick View Add to wishlist -
Sale
Select options This product has multiple variants. The options may be chosen on the product page Quick View Add to wishlist -
Sale
Select options This product has multiple variants. The options may be chosen on the product page Quick View Add to wishlist
Reviews
There are no reviews yet.