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Cancer

INSIG1 Rabbit Monoclonal Antibody

Name: INSIG1 Rabbit Monoclonal Antibody
SKU: KDXB206872
Availability: InStock

$110.00 – $430.00

SKU:KDXB206872 Categories:Monoclonal Antibodies

This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants.

Pack Size	100ul, 1ml, 20ul
Applications	ELISA, IHC-P
Host Species	Rabbit
Ig Isotype	IgG
Antibody Type	Monoclonal Antibody
Organism Species	Human
Concentration	–
Product Synonyms	INSIG1
Observed Mol Wt	30kDa
Alternative Names	CL6; INSIG1
Immunogen (Antigen)	Recombinant protein
Format	Liquid
Buffer Formulation	0.05% BSA, 50% glycerol, PBS with 0.05% proclin300, pH7.3
Reactivity	Mouse, Rat
Uniprot ID	3638
Gene ID	O15503
Potency (Clone Number)	ARC61103
Purification	Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Usage	For Research Use Only. Not for diagnostics or human use.
Shelf Life	12 months at time of shipping
Shipping	Shipped in Dry Ice at -20 Degree Celsius
Storage	Store at -20 Degree Celsius. It is recommended to aliquot and store to avoid repeated freeze-thaw as it affects the stability of the antibody.
Research Areas	Cancer, Cell Biology, Immunology
KD/KO Validated	KD Validated
Disclaimer	The data indicated herein are as indicated and validated in our laboratory. These reagents are for research use only and not for in-vitro diagnostics or human use.