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Cancer

LDL Receptor (LDLR) Rabbit Polyclonal Antibody

Name: LDL Receptor (LDLR) Rabbit Polyclonal Antibody
SKU: KDXB207471
Availability: InStock

$80.00 – $350.00

SKU:KDXB207471 Categories:Polyclonal Antibodies

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Pack Size	100ul, 1ml, 20ul
Applications	ELISA, IF/ICC, IHC-P, WB
Host Species	Rabbit
Ig Isotype	IgG
Antibody Type	Polyclonal Antibody
Organism Species	Human
Concentration	–
Product Synonyms	LDL Receptor (LDLR)
Observed Mol Wt	95kDa
Alternative Names	FH; FHC; FHCL1; LDLCQ2; LDL Receptor (LDLR)
Immunogen (Antigen)	synthetic peptide
Format	Liquid
Buffer Formulation	50% glycerol, PBS with 0.05% proclin300, pH7.3
Reactivity	Human, Mouse, Rat
Uniprot ID	3949
Gene ID	P01130
Purification	Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Usage	For Research Use Only. Not for diagnostics or human use.
Shelf Life	12 months at time of shipping
Shipping	Shipped in Dry Ice at -20 Degree Celsius
Storage	Store at -20 Degree Celsius. It is recommended to aliquot and store to avoid repeated freeze-thaw as it affects the stability of the antibody.
Research Areas	Cancer; Cell Biology; Immunology
KD/KO Validated	KD Validated
Disclaimer	The data indicated herein are as indicated and validated in our laboratory. These reagents are for research use only and not for in-vitro diagnostics or human use.