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Cancer

MLH1 Mouse Monoclonal Antibody [KO Validated]

Name: MLH1 Mouse Monoclonal Antibody [KO Validated]
SKU: KDXB200452
Availability: InStock

$110.00 – $430.00

SKU:KDXB200452 Categories:Monoclonal Antibodies

The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).

Pack Size	100ul, 1ml, 20ul
Applications	ELISA, WB
Host Species	Rabbit
Ig Isotype	IgG1, kappa
Antibody Type	Monoclonal Antibody
Concentration	–
Product Synonyms	[KO Validated] MLH1
Observed Mol Wt	85kDa
Alternative Names	COCA2, FCC2, H1, hMLH1, HNPCC, HNPCC2, LYNCH2, MLH-1, MMRCS1
Immunogen (Antigen)	Recombinant protein
Format	Liquid
Buffer Formulation	50% glycerol, PBS with 0.05% proclin300, pH7.3
Reactivity	Human
Uniprot ID	4292
Gene ID	P40692
Potency (Clone Number)	AMC0417
Purification	Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Usage	For Research Use Only. Not for diagnostics or human use.
Shelf Life	12 months at time of shipping
Shipping	Shipped in Dry Ice at -20 Degree Celsius
Storage	Store at -20 Degree Celsius. It is recommended to aliquot and store to avoid repeated freeze-thaw as it affects the stability of the antibody.
Research Areas	Cancer, Cell Biology, Immunology
KD/KO Validated	KD Validated
Disclaimer	The data indicated herein are as indicated and validated in our laboratory. These reagents are for research use only and not for in-vitro diagnostics or human use.