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Cell Biology

MSH6 Rabbit Polyclonal Antibody [KO Validated]

Name: MSH6 Rabbit Polyclonal Antibody [KO Validated]
SKU: KDXB200463
Availability: InStock

$100.00 – $430.00

SKU:KDXB200463 Categories:Polyclonal Antibodies

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

Pack Size	100ul, 1ml, 20ul
Applications	ELISA, IF/ICC, WB
Host Species	Rabbit
Ig Isotype	IgG
Antibody Type	Polyclonal Antibody
Organism Species	Human
Concentration	–
Product Synonyms	[KO Validated] MSH6
Observed Mol Wt	153kDa
Alternative Names	GTBP, GTMBP, H6, HNPCC5, HSAP, LYNCH5, MMRCS3, MSH-6, p160
Immunogen (Antigen)	Recombinant protein
Format	Liquid
Buffer Formulation	50% glycerol, PBS with 0.01% thimerosal, pH7.3
Reactivity	Human, Monkey, Mouse
Uniprot ID	2956
Gene ID	P52701
Purification	Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Usage	For Research Use Only. Not for diagnostics or human use.
Shelf Life	12 months at time of shipping
Shipping	Shipped in Dry Ice at -20 Degree Celsius
Storage	Store at -20 Degree Celsius. It is recommended to aliquot and store to avoid repeated freeze-thaw as it affects the stability of the antibody.
Research Areas	Cell Biology, Developmental Biology, Immunology
KD/KO Validated	KD Validated
Disclaimer	The data indicated herein are as indicated and validated in our laboratory. These reagents are for research use only and not for in-vitro diagnostics or human use.