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Cancer

PHD2/EGLN1 Rabbit Monoclonal Antibody [KO Validated]

Name: PHD2/EGLN1 Rabbit Monoclonal Antibody [KO Validated]
SKU: KDXB200534
Availability: InStock

$110.00 – $430.00

SKU:KDXB200534 Categories:Monoclonal Antibodies

The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).

Pack Size	100ul, 1ml, 20ul
Applications	ELISA, WB
Host Species	Rabbit
Ig Isotype	IgG
Antibody Type	Monoclonal Antibody
Organism Species	Human
Concentration	–
Product Synonyms	[KO Validated] PHD2/EGLN1
Observed Mol Wt	46kDa
Alternative Names	C1orf12, ECYT3, HALAH, HIF-PH2, HIFPH2, HPH-2, HPH2, N1, PHD2, SM20, ZMYND6
Immunogen (Antigen)	synthetic peptide
Format	Liquid
Buffer Formulation	0.05% BSA, 50% glycerol, PBS with 0.05% proclin300, pH7.3
Reactivity	Human
Uniprot ID	54583
Gene ID	Q9GZT9
Potency (Clone Number)	ARC52542
Purification	Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Usage	For Research Use Only. Not for diagnostics or human use.
Shelf Life	12 months at time of shipping
Shipping	Shipped in Dry Ice at -20 Degree Celsius
Storage	Store at -20 Degree Celsius. It is recommended to aliquot and store to avoid repeated freeze-thaw as it affects the stability of the antibody.
Research Areas	Cancer, Cell Biology, Immunology
KD/KO Validated	KD Validated
Disclaimer	The data indicated herein are as indicated and validated in our laboratory. These reagents are for research use only and not for in-vitro diagnostics or human use.