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Cell Biology

Pseudouridine / 5-ribosyluracil Rabbit Monoclonal Antibody

Name: Pseudouridine / 5-ribosyluracil Rabbit Monoclonal Antibody
SKU: KDXB211310
Availability: InStock

Price range: $110.00 through $430.00

SKU:KDXB211310 Categories:Monoclonal Antibodies

Pseudouridine (?) was among the first post-transcriptional modifications discovered and is overall one of the most abundant?1?. It is present in a wide range of cellular RNAs and is highly conserved across species. ? is derived from uridine (U) via base-specific isomerization catalyzed by ? synthases. The site-specific pseudouridylation goes through either snoRNA-dependent (requires H/ACA RNP) or -independent mechanism (requires pseudouridine synthase (PUS) family enzymes)?2?. It has an extra hydrogen-bond donor at its non-Watson-Crick edge. When incorporated into RNA, ? can alter RNA secondary structure by increasing base stacking, improving base pairing and rigidifying sugar-phosphate backbone5. The chemical and physical properties of RNA can be altered with the incorporation of ?, which could contribute to subsequent cellular functions.

Pack Size	100ul, 1ml, 20ul
Applications	DB, ELISA
Host Species	Rabbit
Ig Isotype	IgG
Antibody Type	Other Modified Antibody
Product Synonyms	Pseudouridine / 5-ribosyluracil
Immunogen (Antigen)	Chemical compounds
Format	Liquid
Buffer Formulation	0.05% BSA, 50% glycerol, PBS with 0.05% proclin300, pH7.3
Reactivity	Species independent
Uniprot ID	CAS: 1445-07-4
Potency (Clone Number)	ARC50719
Purification	Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Usage	For Research Use Only. Not for diagnostics or human use.
Shelf Life	12 months at time of shipping
Shipping	Shipped in Dry Ice at -20 Degree Celsius
Storage	Store at -20 Degree Celsius. It is recommended to aliquot and store to avoid repeated freeze-thaw as it affects the stability of the antibody.
KD/KO Validated	KD Validated
Disclaimer	The data indicated herein are as indicated and validated in our laboratory. These reagents are for research use only and not for in-vitro diagnostics or human use.