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Cancer

PTTG1 Rabbit Polyclonal Antibody

Name: PTTG1 Rabbit Polyclonal Antibody
SKU: KDXB211451
Availability: InStock

Price range: $80.00 through $350.00

SKU:KDXB211451 Categories:Polyclonal Antibodies

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene.

Pack Size	100ul, 1ml, 20ul
Applications	ELISA, IHC-P, WB
Host Species	Rabbit
Ig Isotype	IgG
Antibody Type	Polyclonal Antibody
Organism Species	Human
Product Synonyms	PTTG1
Observed Mol Wt	22kDa
Alternative Names	EAP1; PTTG; ECRAR; HPTTG; TUTR1; PTTG1
Immunogen (Antigen)	Recombinant protein
Format	Liquid
Buffer Formulation	50% glycerol, PBS with 0.02% sodium azide, pH7.3
Reactivity	Human, Mouse, Rat
Uniprot ID	9232
Gene ID	O95997
Purification	Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Usage	For Research Use Only. Not for diagnostics or human use.
Shelf Life	12 months at time of shipping
Shipping	Shipped in Dry Ice at -20 Degree Celsius
Storage	Store at -20 Degree Celsius. It is recommended to aliquot and store to avoid repeated freeze-thaw as it affects the stability of the antibody.
Research Areas	Cancer, Cell Biology, Immunology
KD/KO Validated	KD Validated
Disclaimer	The data indicated herein are as indicated and validated in our laboratory. These reagents are for research use only and not for in-vitro diagnostics or human use.