Serine/threonine protein kinase (STK33) is a 524-residue kinase that belongs to the calcium/calmodulin-dependent family of kinases. STK33 exhibits differential expression in normal and malignant cancer tissue, including hepatocellular carcinoma. STK33 expression is required in the context of mutant KRAS, the most commonly mutated human oncogene, to maintain for cellular viability and proliferation. STK33 depletion via modulation of interacting proteins results in proteasome-mediated degradation of STK33 in human cancer cells, triggering apoptosis.
| Pack Size | 100ul, 1ml, 20ul |
|---|---|
| Applications | ELISA, IF/ICC, WB |
| Host Species | Rabbit |
| Ig Isotype | IgG |
| Antibody Type | Monoclonal Antibody |
| Organism Species | Human |
| Product Synonyms | STK33 |
| Observed Mol Wt | 58kDa |
| Alternative Names | STK33 |
| Immunogen (Antigen) | Recombinant protein |
| Format | Liquid |
| Buffer Formulation | 0.05% BSA, 50% glycerol, PBS with 0.02% sodium azide, pH7.3 |
| Reactivity | Human, Mouse |
| Uniprot ID | 65975 |
| Gene ID | Q9BYT3 |
| Potency (Clone Number) | ARC2330 |
| Purification | Antigen-specific affinity chromatography followed by Protein A affinity chromatography |
| Usage | For Research Use Only. Not for diagnostics or human use. |
| Shelf Life | 12 months at time of shipping |
| Shipping | Shipped in Dry Ice at -20 Degree Celsius |
| Storage | Store at -20 Degree Celsius. It is recommended to aliquot and store to avoid repeated freeze-thaw as it affects the stability of the antibody. |
| Research Areas | Cancer, Cell Biology, Immunology |
| KD/KO Validated | KD Validated |
| Disclaimer | The data indicated herein are as indicated and validated in our laboratory. These reagents are for research use only and not for in-vitro diagnostics or human use. |

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